CGCI: Cancer Genome Characterization Initiative

The Cancer Genome Characterization Initiative (CGCI) uses molecular characterization to uncover distinct features of rare cancers. Current projects perform comprehensive molecular cataloging of HIV+ and other rare adult and pediatric cancers. The research community can use CGCI data to gain insights into the underlying mechanisms of these cancers and identify potential therapeutic targets.

Cancer Genome Characterization Initiative Banner. Links to Program Page

News & Publications

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Cervical Cancer Metastasis
August 03, 2020

Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors...

Banner for Cancer Genome Characterization Initiative
August, 2020

Cervical cancer is the leading cause of cancer death among women in Africa1. This is largely due to patients being diagnosed at later stages of the disease, leading to poor prognosis. Other factors of poor prognosis include high prevalence of genital human...

Headshot of Dr. Andy Mungall
December, 2019

Genome science and advances in sequencing technologies are leading the way towards precision oncology for cancer patients. OCG interviewed Dr. Andrew (Andy) Mungall, Senior Staff Scientist and Group Leader of Biospecimen and Library Cores at Canada’s Michael Smith Genome Sciences Centre of...

Icon for Cancer Genome Characterization Initiative
March, 2019

Burkitt Lymphoma (BL) is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) first described in 1956 by Dr. Denis Burkitt in children from sub-Saharan Africa. Different subtypes of BL exist including endemic BL (eBL) and sporadic BL (sBL), amongst others. Geographic variability exists with...

Strand split artifact reads (SSAR) mapping and diagrammatic depiction of the proposed mechanism
January 25, 2019

Tissues used in pathology laboratories are typically stored in the form of formalin-fixed, paraffin-embedded (FFPE) samples. One important consideration in repurposing FFPE material for next generation sequencing (NGS) analysis is the sequencing artifacts that can arise from the significant...

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Projects

Burkitt Lymphoma

The goal of the Burkitt Lymphoma Genome Sequencing Project (BLGSP) is to explore potential genetic changes in patients with Burkitt lymphoma (BL) that could lead to better prevention, detection, and treatment of this rare and aggressive cancer.

HIV+ Tumor Molecular Characterization Project

The Office of Cancer Genomics (OCG), along with the Office of HIV and AIDS Malignancies (OHAM), initiated the HIV+ Tumor Molecular Characterization Project (HTMCP) to gain insight into the genetic events driving HIV-associated cancers and to determine why certain cancers, but not others, have higher incidences in HIV-positive patients.

Last updated: February 19, 2021