News & Publications

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Publications

CRISPR Cas9
CTD²
Cancer Discovery

Mutations in ARID1A rank among the most common molecular aberrations in human cancer. However, oncogenic consequences of ARID1A mutation in human cells remain poorly defined due to lack of forward genetic models. Here, CRISPR/Cas9-mediated ARID1A knockout (KO) in primary TP53-/- human...

Graphical Abstract for "Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages"
CTD²
Cell

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) atlas, we performed single-cell RNA sequencing (scRNA-seq) of hematopoietic and non-hematopoietic subpopulations from tumor and tumor...

e-Newsletter

Issue 25, February, 2021

HCMI Program Highlights

HCMI organoid banner image
Eva Tonsing-Carter, Ph.D. and Cindy Kyi, Ph.D.
Last updated: June 09, 2021