News & Publications

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Diagram showing cancer cells spreading into the blood stream CRUK 448

Much of what is known about the neurotrophic receptor tyrosine kinase (NTRK) genes in cancer was revealed through identification and characterization of activating Trk fusions across many tumor types. A resurgence of interest in these receptors has emerged owing to the realization that they are...

Mitochondrial Dynamics in Pancreatic Cancer
Nature Chemical Biology

Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However, little is known about its potential as a therapeutic target. We used chemoproteomic profiling and structure-based design to...


Issue 23, December, 2019

Featured Researchers

Headshot of Dr. Andy Mungall
Interviewed by Cindy Kyi, Ph.D.
Last updated: July 29, 2020